Scientists create mice with cells from 2 males for first time

Scientists have created baby mice with two fathers for the first time. 

They turned male mouse stem cells into female cells in a lab. 

The work was described in a study published Wednesday in the journal Nature. 

The researchers took skin cells from the tails of male mice and converted them into “induced pluripotent stem cells,” which have the ability to develop into many different types of cells or tissues. 

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This photo provided by researcher Katsuhiko Hayashi shows mice derived from stem cells, four weeks after their birth, in Osaka, Japan, in September 2021. In a study published Wednesday, March 16, 2023, in the journal Nature, scientists led by Hayashi created baby mice with two fathers for the first time by turning male mouse stem cells into female cells in a lab.  (Katsuhiko Hayashi via AP)

Next, by growing and treating the male stem cells with a drug, they were turned into female cells and produced functional egg cells. 

Those eggs were fertilized, and the scientists implanted the embryos into female mice. 

About 1% of the embryos grew into live mouse pups that appeared to grow normally and became parents themselves, research leader Katsuhiko Hayashi of Kyushu University and Osaka University in Japan told fellow scientists at the Third International Summit on Human Genome Editing last week.

An aerial view of the University of the California San Francisco (UCSF) campus in Mission Bay, San Francisco, with the Salesforce Tower visible in the background May 17, 2022.  (Smith Collection/Gado/Getty Images)

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In commentary published alongside the study, Diana Laird, a stem cell and reproductive expert at the University of California, San Francisco, who was not involved in the research, said the work “opens up new avenues in reproductive biology and fertility research” for animals and people. 

“And it might even provide a template for enabling more people,” such as male same-sex couples, “to have biological children, while circumventing the ethical and legal issues of donor eggs,” she and colleague Jonathan Bayerl said. 

This photo provided by researcher Katsuhiko Hayashi shows a fertile adult male mouse, right, with his offspring and another adult mouse in Osaka, Japan, in September 2021. (Katsuhiko Hayashi via AP)

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They also raised several cautions, including that the technique is extremely inefficient. They also stressed that it’s still too early to know if the protocol would work in human stem cells at all. And Laird highlighted that scientists need to be mindful of the mutations and errors that may be introduced in a culture dish before using stem cells to make eggs.

The Associated Press contributed to this report.