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The Queen will welcome US President Joe Biden and First Lady Jill Biden to Windsor Castle later.
The visit will include a Guard of Honour and tea at the monarch's Berkshire residence.
It comes at the end of the G7 summit in Cornwall, where leaders of the world's biggest economies have discussed issues including vaccines and climate change.
The couple met the Queen on Friday, when she attended a reception for G7 leaders at the Eden Project.
Their latest meeting comes the day after the Queen marked her official birthday with a scaled back Trooping the Colour parade.
This year's celebration saw a reduced parade in the grounds of Windsor Castle, rather than in central London, because of the pandemic.
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image copyrightGetty Imagesimage captionThe Queen met the Bidens at an event at a reception at the Eden Project on Friday
The Queen will greet the Bidens at the dais in the castle's quadrangle.
A Guard of Honour formed of the Queen's Company First Battalion Grenadier Guards will give a Royal Salute, and the US national anthem will also be played.
Mr Biden will then accompany the Officer Commanding the Guard of Honour, Major James Taylor, and Major General Christopher Ghika to inspect the Honour Guard, before returning to the dais to watch the military march-past.
The role of escorting a visiting head of state to inspect the troops was usually carried out by the Duke of Edinburgh, before he retired in 2017.
Prince Philip died in April, aged 99.
image copyrightPA Mediaimage captionThe Queen with the Trumps in 2019
The Queen, 95, first met a serving US president, Harry S Truman, as Princess Elizabeth in 1951.
She has since met all 14 elected US leaders during her 69 years on the throne, except for Lyndon B Johnson.
In 2019 the Queen met then President Donald Trump at Buckingham Palace. They also had afternoon tea together in the castle's Oak Room.
When the monarch met George W Bush at Windsor, they enjoyed a traditional afternoon tea, with sandwiches and cakes in the White Drawing Room.