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Little Mix have made a staggering six studio albums, have toured the world's biggest venues and now even have their own TV show.

Bandmate Jesy Nelson recently left fans crestfallen when she announced her "extended break" from the group for "private medical reasons", being met with an outpouring of support.

And in a recent interview, she told she felt robbed of her innocence by fame.

The 29-year-old first sparked concern when it was announced she would not be appearing at the MTV EMAs digitial ceremony with bandmates Perrie Edwards, Leigh-Anne Pinnock and Jade Thirlwall.

Nor would she appear on the final of their show, The Search.

A rep for the band said at the time: "Jesy is unwell and will not be appearing on tonight's final of Little Mix The Search.

"She will also not be hosting or performing at tomorrow's MTV EMAs."

No further information was given about Jesy's condition.

The girls are known for their hard work
(Image: BBC/Modest TV/Zoe McConnell)

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The girls are renowned for their hard work, having put out six albums in just nine years.

They became household names in 2011 when they each appeared separately on the X Factor, only to form a group under the wing of head honcho Simon Cowell.

They went on to win the show, and the following year returned with a performance from their upcoming album.

Jesy pulled out of tonight's The Search and the MTV EMAs
(Image: Twitter)

And since then, they've pretty much worked non-stop with the release of their albums – all of which have been bestsellers – and constant globe-trotting as they hit up the world's most prestigious venues.

But fame can come with a dark side, the girls often opening up about the drawbacks of international megastardom.

Jesy, in particular, has been open – telling of her heartbreaking experiences with online trolls.

They've been working non-stop for nine years

In a recent interview with the Mail on Sunday's You Magazine, Jesy told she feels reticent about having kids after her experiences with social media – and that she feels robbed of her innocence by fame.

When Leigh-Anne expressed concern for her future kids, Jesy added: "It makes me not want to have a kid.

"Those insecurities that we all have now because of social media, imagine having that embedded in you as a child."

They've made six albums and performed at the world's biggest venues
(Image: BBC/Modest TV/Callum Mills)

She added: "Don't get me wrong, I'm not going to sit here and say we've got a terrible life, because we haven't, but I do think our innocence was taken from us."

Jesy told last year about how she had tried to take her own life because of the bullying.

"I wasn't known as one of the singers from Little Mix," she recalled in her eye-opening BBC documentary, Jesy Nelson: Odd One Out.

Jesy told of their 'gruelling schedule'
(Image: BBC)

"I was always known as the ugly one."

She told The Guardian how her management had offered her time off to deal with her troubles, but she refused over fears her absence would prompt even more negativity to come her way.

"Our schedule was so gruelling," Jesy shared. "I was going to see a therapist at six o'clock in the morning, crying, and then going to a photoshoot."

Jesy wasn't the only band member to feel the pressure of their hectic schedule after Jade split from long-term ex Jed Elliott in August last year.

Their schedules had left them barely any time together.

Before they went their separate ways, Jade remarked: "I'm scared. He's going to America and we're headed all over the place, too. It's going to be really hard but we will FaceTime and hopefully he will come and watch us. We'll see."

Jade and Jed split last year amid hectic schedules
(Image: Getty)

They told us that they're always stronger as one unit

Leigh-Anne, meanwhile, has publicly spoken out about how she's struggled with fame – particularly being targeted by racist trolls.

She appeared earlier this year on The Talk with her parents, in which Black Brits discussed their experiences of racism.

And last year she told Lorraine Kelly that having to deal with it "in the public eye" made it especially tough.

Leigh-Anne opened up about her experiences of racism on The Talk
(Image: Channel 4)

The girls comforted Perrie as she cried on stage back in 2015

And Perrie, after rocketing to fame as a teen with the band, would often read the negative comments posted about her online.

"Someone once wrote that I had 'cankles' and now I have issues with my ankles," she admitted.

In New York in 2015, Perrie broke down in tears on stage following her split from One Direction fiancé Zayn Malik.

But the girls have always been on hand to help each other.

At the BRITs in 2019, they told the Mirror: "We're always stronger when we are together. That's always been our line."

If you're struggling and need to talk, the Samaritans operates a free helpline open 24/7 on 116 123. Alternatively, you can email [email protected] if you'd prefer to write down how you feel. You are not alone.